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In addition, excessive ROS production can lead to oxidative stress, which in turn affects sperm nuclear DNA, sperm mitochondrial respiratory activity 40 and endocrine function, leading to a variety of male reproductive system disorders, and consequently may lead to male infertility 41,42

The most common reported effect of smoking tobacco alongside cannabis is an intensification of the high, although some report that tobacco use actually has the opposite effect and reduces the high

None of the authors have been involved in legal or regulatory matters related to the contents of this paper

Sources: Carhart-Harris, R

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